Have researchers really ‘de-extincted’ the dire wolf? No, but behind the hype was a genuine breakthrough
The pups are cute – and great for PR – but they’re modified grey wolves. The real work is being done with their red cousinsThu 10 Apr 2025 15.50 BSTShare109
I’ve been waiting for this. Ever since researchers almost brought a wild goat species back from extinction in 2003, it was only a matter of time until someone came forward and said they had successfully “de-extincted” a species. Now, it has happened.
This week, American biotech company Colossal Biosciences announced it had resurrected the dire wolf, an animal that went extinct at the end of the last ice age. Colossal released a video that invited viewers to “experience the first dire wolf howls heard in over 10,000 years”.
But these are not dire wolf howls, and these are not dire wolves. To make the pups, scientists edited the DNA inside grey wolf cells to make it more dire wolf-like. Twenty changes were made to 14 different genes involved in coat colour, body size and skull shape. Then the cells were used for cloning.
CVD 